My journey through TT and a suspicious for cancer diagnosis, part one. I was told that my thyroid needs to be removed (at least half, possibly all). That was a hard Thanksgiving. The Afirma Genomic Sequencing Classifier (GSC) (Veracyte, San Francisco, CA) is a cancer rule-out test that partners whole transcriptome RNA sequencing with machine learning to categorize nodules as benign or suspicious. The results were suspicious of papillary cancer, but not conclusive. Epub 2018 Apr 10. They were incredibly supportive and also concerned. Results: Afirma result was suspicious in 69 cases. 2. Any Insights? Is is the Benign that is a false negative ? PollAfirma GSC Biospy Result - Thyroid cancer - Inspire They sent me home with 125mcg of Synthroid, calcitrol, and calcium. The current Afirma Genomic Sequencing Classifier (GSC) demonstrates improved specificity, suggesting more nodules will have a benign result (benign call rate [BCR]), but independent data are needed to confirm this in clinical practice. And the 3rd test was Afirma which came back "suspicious". Finally, the cells were sent to Afirma, Now I was growing concerned. Polavarapu P, Fingeret A, Yuil-Valdes A, Olson D, Patel A, Shivaswamy V, Matthias TD, Goldner W. J Endocr Soc. The Affirma Xpression Atlas is based on RNA sequencing. Home Patients Portal Clinical Thyroidology for the Public October 2016 Vol 9 Issue 10 p.11-12, CLINICAL THYROIDOLOGY FOR THE PUBLIC Afirma Gene Sequencing Classifier Compared with Gene - PubMed Lastly I do 25mcg of levothyroxine once a day for Hypothyroidism, it was prescribed based on lab results, not on how I was feeling. I called my husband before I even received the callback, and couldn't stop crying. Nishino M, Mateo R, Kilim H, Feldman A, Elliott A, Shen C, Hasselgren PO, Wang H, Hartzband P, Hennessey JV. http://www.glandsurgery.org/article/view/1002/1193 Biotech Strategy Blog in this post by Pieter Droppert June 28,2012 Also mentions 48% of nodules falsely called "suspicious" for cancer and can cause many people to have unnecessary thyroid surgery when they don't have cancerous thyroid cells! She also said that her endo said that all of his colleagues stopped using this test and that in their experience the number of suspicious that came back cancerous is the same as what you find in the general population. Molecular markers can be used in thyroid biopsy specimens to either to diagnose cancer or to determine that the nodule is benign. BACKGROUND microRNA: a short RNA molecule that has specific actions within a cell to affect the expression of certain genes. I have found this community very informative, thank you. Recently I change insurance and in doing so, my new doctor ordered a ultrasound which showed the nodule and he felt it was nothing to worry about. Thanks for chiming in. I called and almost everyone has that risk if it is suspicious. That didn't sit well with me. 5) What are your thoughts on these results? The overall PPV of an Afirma GSC suspicious nodule was 47%, regardless of variant/fusion status. Background: WHAT ARE THE IMPLICATIONS OF THIS STUDY? I've read a lot about this test (both good and bad). Just underwent Afirma and Asurgen testing on the suspicious one. Dr.Hershman then says, In a world where there are unlimited financial resources,both the oncogene and the GEC methods could be applied to all indeterminate nodules,but this approach is not practical currently. It mentions possible microcalcification, which has never come up before. Here's what a friend of mine wrote who is a retired neurologist: "They can both be right for different reasons, or from different perspectives. So frustrating!! result (eg, benign or suspicious) Public Comment. Surgical margins: negative for tumor (tumor is < 0.1cm from margin) Living beings depend on genes, as they code for all proteins and RNA chains that have functions in a cell. PMC Genes: a molecular unit of heredity of a living organism. -Lymph Node US: Mostly clear in neck, 1 ovoid focus in submandibular region that may be enlarged LN or Submandibular Lesion The moment that I've been so nervous about finally came yesterday. The Afirma Xpression Atlas for thyroid nodules and thyroid cancer Living beings depend on genes, as they code for all proteins and RNA chains that have functions in a cell. It's barely even hoarse. 2016 Jul;26(7):911-5. doi: 10.1089/thy.2015.0644. Personally, I think getting the AFIRMA test done is a good thing. I'm looking for any and all help and/information you can share with me. Afirma Suspicious results - Thyroid cancer - Inspire

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