6). reviewed, edited and finalised the manuscript. https://doi.org/10.1016/j.bbrc.2020.11.095 (2021). Carrageenan Nasal Spray for COVID-19 Prophylaxis (ICE-COVID) Elife 10, e69302. Initial report of decreased SARS-CoV-2 viral load after inoculation with the BNT162b2 vaccine. Study endpoints were presented by descriptive statistics, aiming to compare the course of viral load between the three treatment groups. . Sci Rep 13, 6839 (2023). 76, 469475. SARS-CoV-2 infection progression starts with viral entrance mediated by the spike glycoproteins interaction with the host ACE2 receptor molecule. 1). The product targets a stable site on the spike protein of the virus that is not known to mutate. the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Med. A nasal and mouth spray called "IGM-6268" is in the early stages of clinical trials. Absolute changes of total symptom scores from baseline (day 1) until day 11 of treatment (ITT analysis set). 2005 - 2023 WebMD LLC, an Internet Brands company. A., Dion, S. P., Buchholz, D. W., Imbiakha, B., Olmstead, A. D., Jager, M., Dsilets, A., Gao, G., Martins, M., Vandal, T., Thompson, C. A. H., Chin, A., Rees, W. D., Steiner, T., Nabi, I. R., Marsault, E., Sahler, J., Diel, D. G., . Health-related quality of life in patients with COVID-19; international development of a patient-reported outcome measure. Nasal defence sprays Products such as Vicks First Defence nasal spray claim to trap and neutralise viruses in the nose before they have a chance to develop and spread. contributed to the study conceptualisation. J. Infect. Anna R. Mkel, PhD, senior scientist, Department of Virology, University of Helsinki, Finland. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Various studies have looked at the role of different foods in preventing coronavirus infection severe Covid-19 These include seaweed and grapefruit-based nasal sprays, dark chocolate, tuna. . Vitiello, A., Ferrara, F., Troiano, V. & La Porta, R. COVID-19 vaccines and decreased transmission of SARS-CoV-2. PubMed J. Correspondence to The reduction in virus load over the entire treatment period was clinically meaningful for all three groups (p<0.0001 for both genes). Shapira, T., Monreal, I. By application of a novel computational approach based on Shannon entropy homology, Konrat et al. Upon treatment, a gradual decline of viral load from baseline (day 1) to day 11 of treatment was observed in all three study groups. Data was analysed primarily exploratively; there was no formal testing of a given hypothesis. Center for Molecular Medicine Cologne (CMMC), Faculty of Medicine and University Hospital, University of Cologne, Kerpener Str. The current study was a randomized, parallel, double-blind, placebo-controlled trial. Amdal, C. D. et al. https://doi.org/10.1089/088318703322751327 (2004). Thank you for visiting nature.com. https://cornellsun.com/2022/04/27/cornell-research-team-to-develop-covid-19-nose-spray-treatment/, Shapira, T., Monreal, I. Three-group comparisons were analysed with KruskalWallis test. Levine-Tiefenbrun, M. et al. H.G., M.S., and F.K. Those compounds were tested in human lung and colon cells that were then exposed to SARS-CoV-2. Of note, we cannot rule out the possibility that the placebo (nasal spray buffer) contributed to viral clearance. Multinomial regression analysis was done to 26 determine the association between nasal carriage of Bacillus and COVID-19 severity after 27 adjusting for age, sex, and co-morbidity status. https://doi.org/10.1038/s41598-023-32546-z, DOI: https://doi.org/10.1038/s41598-023-32546-z. The experimental drug works in mice, and researchers believe it may be effective in humans. In a subset of patients (initial Ct<25) viral load was strongly reduced on day 4 in the 0.1% group compared to placebo (p=0.005). Pharmacol. Expert. Patients were assigned a treatment number in an ascending mode according to their chronological order of inclusion. Jean, F. (2022). Striking antibody evasion manifested by the Omicron variant of SARS-CoV-2. Expert Opin. Odhar, H. A. et al. Article On days 1, 5, 8 and 11, patients completed the standardized SF-36 questionnaire of quality of life. reported that a low pH hypromellose nasal powder spray containing common components of nasal sprays could reduce SARS-CoV-2 infection rates19. The dual-target RT-PCR independently targets the ORF1a/b and the sarbecovirus E genes, and assays were considered positive if at least one target returned a positive result (Ct values reflecting an inverse relationship with viral load). Inflammopharmacology 29(5), 14. During the course of the treatment, all study groups showed clear improvements of symptoms (Fig. WebMD does not provide medical advice, diagnosis or treatment. Of note, the mean viral load value showed small variability, thereby supporting the power of the current study. Samples of day 1 represent pre-treatment baseline samples. Open Access funding enabled and organized by Projekt DEAL. After treatment, virus load was reduced in all groups (p<0.0001) but was greater in the 0.1% group compared to placebo (p=0.007). Multinomial regression analysis was done to 26 determine the association between nasal carriage of Bacillus and COVID-19 severity after 27 adjusting for age, sex, and co-morbidity status. Importantly, the AUC analysis depicting the viral load decrease based on the detection of the ORF 1a/b gene over the 11-day treatment period showed a significantly greater reduction of virus load in the 0.1% azelastine group compared to placebo. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. The researchers picked four compounds that worked at very low concentrations and did not negatively affect the host cells. Thus, it should be kept in mind that treatment started at a time point where the peak of viral load had probably passed. Our study population was characterized by an initial mean viral load of log10 6.851.31cp/mL, which was higher than more recently reported SARS-CoV-2 viral load values26. Boots nasal spray containing seaweed could fight Covid-19 It should be noted that the SARS-CoV-2 alpha variant (B.1.1.7) was the dominant variant in Germany during the enrolment phase of the current study16. Boots Dual Defence Nasal Spray is used to dampen the symptoms of cold and flu. 16, 275282.

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